Our research areas and field of interest include 3D Organ-On-Chip Solutions with emphasis on:
Human Stem Cell Technology
Embryonic cells have unlimited capacity for self-renewal through indefinite cell division. They are called pluripotent as they can differentiate cells from all three germ layers to define the varied and complex tissues of the human organism. Induced pluripotent stem cells (iPSC) are genetically modified mature body cells that behave like embryonic ones. With iPSC scientists recapitulate human evolution, discover how different functions originate and demonstrate how dysfunctions occur. Moreover, iPSC conserve individual genetic background information and are therefore very useful for displaying specific diseases.
3D tissues or organoids engineered from stem cells represent a more sophisticated structure as is seen in certain tissue that comprise a diverse set of cell types and their defined positions. Using brain organoids instead of single neurons or glia cells (2D cells) increase the accuracy in modeling brain diseases and testing therapeutics.
With microfluidic devices, liquid samples can be manipulated at the microliter scale. Organ-on-chips are novel cell or tissue culture plates supported by microfluidics. This technology has gained enormous prominence in various medical research fields and point of care diagnostics. It enables not only fast and inexpensive lab analysis but also guarantees high performance and precision.
Although scientists endeavor to unlock the complexity of the human brain, most questions regarding the central nervous system (CNS) remain open. An aging world population faces a high risk for degradation of cognitive and motor skills as seen in Parkinson's, Alzheimer's and various forms of brain impairment. Studies have shown that early intervention can prevent the development of those diseases. To achieve this, the main focus must lay in understanding the biology which defines brain degeneration.
The blood-brain-barrier, a protective boundary highly regulates the transport of chemicals into the brain which often creates an impediment to drug delivery. With the help of nanomedicine, new strategies have been established to penetrate the blood-brain-barrier for transferring therapeutics to their destination and test their safety.